Update on transgenic animal technology

Application of Transgenic Technology in Animal Agriculture

Significant advancements have been made in bovine transgenic technology in the past 20 years. Currently, it is possible to target genetic sequences into predetermined sites in the host DNA, to transfer independent microchromosomes with the capacity to carry hundreds of genes into the bovine genome and to sequentially introduce multiple genetic modifications into a single genome. The most likely...

Recent Advances and Applications of Transgenic Animal Technology

The necessity of transgenic technology in sustainable production

It has been more than half a century that plant geneticists and breeders have been trying to assemble a combinationof genes in crop plants, in order to make them as suitable and productive as possible. Plant transformation technology incrop plants was first undertakenin the 1980s based on the ability of foreign gene integration into host plant genome andregeneration of transformed plant cells i...

An update on lupus animal models.

PURPOSE OF REVIEW The complexity and heterogeneity of the clinical presentation in systemic lupus of erythematosus (SLE), combined to the inherent limitations of clinical research, have made it difficult to investigate the cause of this disease directly in patients. Various mouse models have been developed to dissect the cellular and genetic mechanisms of SLE, as well as to identify therapeutic...

The Transgenic Animal Models

Shortly after discovery of ET-1 in 1988, the entire endothelin system was characterized. The endothelin system consists of the three peptides ET-1, ET-2 and ET-3, their G-protein-coupled receptors endothelin receptor A and B (ETRA and ETRB) and the two endothelin-converting enzymes (ECE-1 and ECE-2). Genetically modified animal models are an important tool in biomedical research. Here we descri...